Peer-Reviewed Articles

  1. Wegiel B, Bjartell A, Ekberg J, Gadaleanu V, Brunhoff C, Persson J. A role for cyclin A1 in mediating the autocrine expression of VEGF in prostate cancer.  2005;24:6385-6393.
  2. Loboda A, Jazwa A, Wegiel B, Jozkowicz A, Dulak J. Heme oxygenase-1-dependent and -independent regulation of angiogenic gene expression: effect of cobalt protoporphyrin and cobalt chloride on VEGF and IL-8 synthesis in human micorvascular endothelial cells. Cell Mol Biol. 2005;51:347-355.
  3. Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE. Carbon monoxide protects in established hypertension.  J Exp Med. 2006;203:2109-2119.
  4. Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, Gallo D, Cszimadia E, Bach FH, Lee PJ, Otterbein LE. Hypoxia-inducible factor 1-a stabilization by carbon monoxide results in cytoprotective preconditioning.  2007;104:5109-5114.
  5. Haschemi A, Wagner O, Marculescu R, Wegiel B, Robson, SC, Gagliani N, Gallo D, Chen J-F, Bach FH, Otterbein LE. Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages.  J Immunol. 2007;178:5921-5929.
  6. Wegiel B, Bjartell A, Culig Z, Persson JL. Interleukin-6 activates PI3K/Akt signaling pathway and regulates the expression of cyclin A1 to promote tumor survival in prostate cancer.  Int J Cancer. 2008;122(7):1521-1529.
  7. Wegiel B, Chin BY, Otterbein LE. Inhale to survive, cycle or die? Carbon monoxide and cellular proliferation. Cell Cycle. 2008;7 (10):1379-1384
  8. Wegiel B, Bjartell A, Tumolea J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Harkonen P, Persson JL. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.  J Natl Cancer Inst. 2008;100:1022-1036.
  9. Wegiel B, Ekberg J, Talasila KM, Jalili S, Persson JL; Co-operative role of VEGF and p27 Kip1 in acute myeloid leukaemia. Leukemia. 2009;23(2):251-61.
  10. da Silva CG, Specht A, Wegiel B, Ferran C, Kaczmarek E. Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. Circulation. 2009; 119(6):871-9.
  11. Wegiel B, Baty CJ, Gallo D, Csizmadia E, Scott JR, Akhavan A, Chin BY, Kaczmarek E, Alam J, Bach FH, Zuckerbraun BS, Otterbein LE. Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via PI3K and Akt. J Biol Chem. 2009 Aug 7;284(32):21369-78. (highlighted in Science Stke)
  12. Wegiel B, Jiborn T, Abrahamson M, Otterbein LE, Helczynski L, Persson JL and Bjartell A; Cystatin C is downregulated in prostate cancer and modulates invasion of prostate cancer cells via MPK/Erk and androgen receptor  Plos One. 2009 Nov 23;4(11):e7953.
  13. Wegiel B, Persson JL. Effect of a Novel Botanical Agent Drynol Cibotin on Human Osteoblast Cells and Implications for Osteoporosis: Promotion of Cell Growth, Calcium Uptake and Collagen Production. Phytother Res. 2010 Jun;24 Suppl 2:S139-47.
  14. Wegiel B, Gallo D, Raman K, Karlsson J, Ozanich B, Chin BY, Tzeng E, Ahmad S, Ahmed S, Baty C, Otterbein LE. Nitric Oxide-Dependent Endothelial Progenitor Cell Mobilization by Carbon Monoxide Enhances Endothelial Repair Following Vascular Injury. Circulation. 2010 Feb 2;121(4):537-48.
  15. Bil J, Wlodarski P, Winiarska M, Kurzaj Z, Issat T, Jozkowicz A, Wegiel B, Dulak J, Golab J. Photodynamic therapy-driven induction of suicide cytosine deaminase gene. Cancer Lett. 2010 Apr 28;290(2):216-22.
  16. Hanto DW, Maki T, Yoon MH, Csizmadia E, Chin BY, Gallo D, Konduru B, Kuramitsu K, Smith NR, Berssenbrugge, Attanasio C, Thomas M, Wegiel B, Otterbein LE. Intraoperative Administration of Inhaled Carbon Monoxide Reduces Delayed Graft Function in Kidney Allografts in Swine. Am J Transplant. 2010 Nov;10(11):2421-30.
  17. Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B*. Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telengiectasia mutated (ATM) protein. PNAS. 2011 Aug 30;108(35):14491-6. (*corresponding author)
  18. Wegiel B, Gallo D, Csizmadia E, Kaczmarek E, Rogers T, Harris C, Zuckerbraun B, Otterbein LE. Biliverdin Inhibits TLR4 Expression via Nitric Oxide-Dependent Nuclear Translocation of Biliverdin Reductase. PNAS. 2011; Nov 15;108(46):18849-54.
  19. Banerjee P, Basu A, Wegiel B, Otterbein LE, Mizumura K, Gasser M, Waaga-Gasser AM, Choi AM, Pal S. Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis and autophagy-regulating molecules. J Biol Chem. 2012 Sep 14;287(38):32113-23.
  20. Wegiel B*, Gallo D, Csizmadia E, Harris C, Belcher J, Vercellotti GM, Penacho N, Seth P, Sukhatme V, Ahmed A, Pandolfi PP, Helczynski L, Bjartell A, Persson JP, Otterbein LE; Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth. Cancer Res. 2013 Dec 1;73(23):7009-21. (cover of December Issue) (*co-corresponding author)
  21. Li M, Gallo D, Csizmadia E, Otterbein LE, Wegiel B*; Carbon monoxide induces chromatin remodeling to facilitate endothelial cell migration. Thromb Haemost. 2014 May 5;111(5):951-9. (*corresponding)
  22. Wegiel B*, Hedblom A, Li M, Gallo D, Csizmadia E, Harris C, Nemeth Z, Zuckerbraun B, Soares M, Persson JL, Otterbein LE. Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells. Cell Death Dis. 2014 Mar 20;5:e1139. (*corresponding author)
  23. Bisht K, Wegiel B, Tampe J, Neubauer O, Wagner KH, Otterbein LE, Bulmer AC. Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling. Biochem Biophys Res Commun. 2014 Jun 20;449(1):94-9.
  24. Ahmad S, Hewett P, Fujisawa T, Sissaoui S, Cai M, Gueron G, Cudmore M, Admed SF, Wong MKK, Wegiel B, Otterbein LE, Vitek L, Ramma W, Wang K, Ahmed A. Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor-2 phosphorylation. Thromb Haemost. 2015 Feb;113(2):329-37.
  25. Wegiel B, Larsen R, Gallo D, Chin BY, Harris C, Mannam P, Kaczmarek E, Lee P, Zuckerbraun BS, Flavell R, Soares MP and Otterbein LE. Macrophages sense and kill bacteria through carbon monoxide-dependent inflammasome activation. J Clin Invest. 2014 Nov;124(11):4926-40.
  26. Nemeth Z, Li M, Seth P, Csizmadia E, Dome B, Johansson M, Persson J, Otterbein LE, Wegiel B*. Heme oxygenase-1 in macrophages controls prostate cancer progression. Oncotarget. 2015 Oct 20;6(32):33675-88. (*corresponding)
  27. Nemeth Z, Csizmadia E, Vikstrom L, Li M, Bisht K, Feizi A, Otterbein S, Zuckerbraun B, Costa D, Pandolfi PP, Fillinger J, Döme B, Otterbein LE, Wegiel B*. Alterations of Tumor Microenvironment by Carbon Monoxide Impedes Lung Cancer Growth. Oncotarget. 2016 Apr 26;7(17):23919-32. (*corresponding)
  28. Wegiel B*, Wang Y, Li M, Jernigan F, Sun L*. Novel Indolyl-chalcones Target Stathmin to Induce Cancer Cell Death. Cell Cycle. 2016 May 2;15(9):1288-94. (*co-corresponding)
  29. Wang Y, Hedblom , Koerner SF, Li M, Jernigan FE, Wegiel B*, Sun L*. Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5703-5706. (*co-corresponding)
  30. Maria Serena Longhi, Marta Vuerich, Alireza Kalbasi, Jessica E. Kenison, Ada Yeste, Eva Csizmadia, Byron Vaughn, Linda Feldbrugge, Shuji Mitshuhashi, Wegiel B, Leo Otterbein, Alan Moss, Francisco J. Quintana, Simon C. Robson. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. May 4, 2017, JCI Insight
  31. Seth P*, Csizmadia E, Hedblom A, Vuerich M, Xie H, Li M, Longhi MS, Wegiel B*. Deletion of lactate dehydrogenase-A in myeloid cells triggers antitumor immunity. Accepted April 24, 2017, Cancer Research (*co-corresponding) (cover of July issues)

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Reviews

  1. Dulak J, Zagorska A, Wegiel B, Loboda A, Jozkowicz A.  New strategies for cardiovascular gene therapy: regulatable pre-emptive expression of pro-angiogenic and antioxidant genes. Cell Biochem Biophys 2006;44:31-41.
  2. Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH.  Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal 2007; 9:2175-2185.
  3. Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE. Heme oxygenase and carbon monoxide initiate homeostatic signaling.  J Mol Med 2008;86(3):267-279.
  4. Wegiel B, Otterbein LE. Heme oxygenase-1. Molecule Pages Nature Signaling Gateways, 2009 UCSD 2 Apr 2009, doi:10.1038/mp.a004120.01.
  5. Wegiel B, Evans S, Hellsten R, Otterbein LE, Bjartell A, Persson JL Molecular Pathways in the Progression of Hormone-Independent and Metastatic Prostate Cancer. Curr Cancer Drug Targets. 2010 Jun;10 (4):392-401.
  6. Wegiel B, Otterbein LE; Go green: antinflammatory role of biliverdin reductase. Frontiers in Pharmacology; 2012, in press
  7. Wegiel B, Hanto D, Otterbein LE. The social network of carbon monoxide in medicine. Trends in Molecular Medicine, Trends Mol Med. 2013 Jan;19(1):3-11 (cover of January issue)
  8. Wegiel B*, Nemeth Z, Costa M, Bulmer A, Otterbein LE. Heme oxygenase-1: a metabolic Nike. Antioxidant redox Signaling, Forum Issue, in press 2013 (*corresponding)
  9. Eguchi T, Prince T, Wegiel B, Calderwood SK. Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer. J Cell Biochem. 2015 Apr 21.
  10. Wegiel B, Hauser C, Otterbein LE, Heme as a danger molecule in pathogen recognition. FRBM, 2016

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Theses

  1. Wegiel B. Genetic approach to the role of heme oxygenase-1 in human keratinocytes. Construction of AAV vectors. M.Sc in Biotechnology (Molecular Biology); June, 2004.
  2. Wegiel B.  The role of biliverdin/biliverdin reductase and carbon monoxide in the initiation of PI3K-Akt signaling in macrophages and endothelial cells.  Ph.D. in Biochemistry; July 5, 2006.
  3. Wegiel B.  Cellular pathways in angiogenesis and tumor cell invasion in prostate cancer.  Ph.D. in Clinical Sciences (Urology); September 11, 2007.
  4. Wegiel B. Heme Metabolism in Cancer Biology, D.Sc. in biological sciences; December 13, 2016.

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Book Chapters

  1. Wegiel B, Otterbein LE: Heme-originated gas molecule in DNA repair and cancer. iConcept Press ‘ The research and Biology of Cancer. 2013.
  2. Li M and Wegiel B: Role and Metabolism of heme-derived iron in Cancer. iConcept Press ‘Understand Cancer- Research and Treatment’ 2015

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Editorals

  1.  Wegiel B, Ahmed A. “ Nucleosome debris” provokes coagulation and inflammation”. Thromb Res. 2016 Jan;137:1-2.

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