Barbara Wegiel

Principal Investigator: Barbara Wegiel, Ph.D., D.Sc.

My work has contributed to understanding the intermeshed roles of immuno-oncology, stress responses and innate immunity, heme biology in various diseases including cancer.

My research contributed to multiple key discoveries, including:

  • the discovery of cell surface biliverdin reductase and its signaling
  • the identification of ATP as a pathogen-associated molecular pattern
  • the discovery that cyclin A1 directly induces VEGF and MMP levels and cancer metastases
  • the discovery that HO-1/CO controls DNA repair, responses to chemotherapeutics and cancer growth
  • novel role of labile heme in regulation of G-quadruplex-mediated gene regulation in prostate cancer
  • first description of the role of Hx, a heme scavenger, in controlling of cancer growth and GI injury

Links:
Beth Israel Deaconess Medical Center Profile
Harvard Catalyst Profile
Dana Farber/Harvard Cancer Center Profile

Read an interview with Dr. Wegiel: http://www.jci.org/posts/213.

Team

Philippa Seika, MD

Mckenzie O’Connell, BS

Liam Geyer, BS

Immunohistochemistry Specialist:

Eva Csizmadia, MSc 

Former lab members:

Vivien Throm (Research Intern/Master Student)

Yuka Okusha, PhD (Postdoctoral Fellow)

Sahana Asokan (Research Intern)

Monika Janikova, M.Sc.  (PhD student)

Anindhita Meena Muralidharan (Research Intern/Master Student)

Ceren Özerdem (Research Intern)

Giacomo Canesin, PhD (Postdoctoral Fellow/ Instructor)

Andreas Hedblom, PhD (Postdoctoral Fellow)

Seyed Mahdi Hejazi, Pharm Dr., MSc. (Research Intern)

Tasneem Cheytan, MSc (Research Intern)

Reeham Choudhury (Research Student)

Mailin Li, BS (Research Student/Research Assistant)

Zsuzsanna Nemeth, PhD (Postdoc)

Juliana Ariffin, PhD (Postdoc)

Julia Blanter, PhD (Summer student)

Lisa Vikstrom Lilijebjorn, MSc (Research Student)

Samuel Park (Summer student)

Kavita Bisht, PhD (PhD Student)